Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C

Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C.

BACKGROUND & AIMS In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome. METHODS One hundred eighty-one patients with chronic hepatitis C who had been treated with interferon alfa for 12 months (median follow-up, 49 ...

Long-term outcome after interferon therapy in patients with chronic hepatitis C.

Hepatitis C virus antibody titration in patients with chronic hepatitis C, before and after interferon treatment.

We measured hepatitis C virus antibody titers in 13 patients with chronic hepatitis C to determine whether titration of hepatitis C virus antibody was useful or not, to predict and evaluate the efficacy of interferon (IFN) treatment. During administration of IFN, hepatitis C virus titers declined in all patients. Antibody titers performed before treatment as well as just at the end of treatment...

Danazol one Month Treatment of Thrombocytopenia in Chronic Hepatitis C

Thrombocytopenia is frequently observed in patients with chronic hepatitis C virus. Moderate and severe thrombocytopenia (<75,000/mm3) may interfere with diagnostic or therapeutic elective procedures and can be a limiting factor when considering these interventions. The aim of this study was to evaluate the efficacy of one month Danazol treatment for increasing and maintaining platelet levels i...

Interferon signaling and treatment outcome in chronic hepatitis C.

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The current standard therapy for chronic hepatitis C (CHC) consists of a combination of pegylated IFN alpha (pegIFNalpha) and ribavirin. It achieves a sustained viral clearance in only 50-60% of patients. To learn more about molecular mechanisms underlying treatment failure, we investigated IFN-induced signal...